Extraocular muscle function is impaired in ryr3−/− mice
نویسندگان
چکیده
منابع مشابه
The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin.
The extraocular muscles are one of few skeletal muscles that are structurally and functionally intact in Duchenne muscular dystrophy. Little is known about the mechanisms responsible for differential sparing or targeting of muscle groups in neuromuscular disease. One hypothesis is that constitutive or adaptive properties of the unique extraocular muscle phenotype may underlie their protection i...
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The paradigm that an "underacting" extraocular muscle is always atrophic or hypoplastic and that an overacting extraocular muscle should always be enlarged leads to inconsistencies with clinical observations. These include findings of "overacting" inferior oblique muscles, superior rectus muscle overaction or contracture syndrome, and normal extraocular muscle diameters in patients with apparen...
متن کاملAccessory extraocular muscle.
Although on cover test the child maintained fixation easily with either eye, he preferred to view with the right eye. A marked left convergent strabismus was present, the deviation being greater on accommodation; the cover test also showed alternating hypertropia. When fixing with the right eye the horizontal deviation was approximately 35A with left hypertropia and when fixing with the left ey...
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GPRC6A is a widely expressed orphan G protein-coupled receptor that senses extracellular amino acids, osteocalcin, and divalent cations in vitro. GPRC6A null (GPRC6A(-/-)) mice exhibit multiple metabolic abnormalities including osteopenia. To investigate whether the osseous abnormalities are a direct function of GPRC6A in osteoblasts, we examined the function of primary osteoblasts and bone mar...
متن کاملMuscle function of knee extensors and flexors after stroke is selectively impaired at shorter muscle lengths.
OBJECTIVE To investigate whether muscle strength is selectively more affected at shorter lengths of thigh muscles as result of stroke and to determine whether this is associated with impaired neural activation at shorter muscle lengths. DESIGN Case-control study. SUBJECTS Fourteen patients with sub-acute stroke, and 12 able-bodied controls. METHODS In patients (bilaterally) and able-bodie...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2019
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.201912333